R140G (p.Arg140Gly) variant of HTR2A (5-hydroxytryptamine receptor 2A)
R140G (p.Arg140Gly) in HTR2A (5-hydroxytryptamine receptor 2A) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data, published literature, and structural context.
R140G (p.Arg140Gly) variant details
- p.Arg140Gly
- gnomAD 13-46892585-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.22
- REVEL 0.07
- MetaLR 0.17
- MetaSVM -0.93
- CADD 21.90
- PolyPhen-2 0.00
- SIFT 0.42
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available