L61F (p.Leu61Phe) variant of HTR2A (5-hydroxytryptamine receptor 2A)
L61F (p.Leu61Phe) in HTR2A (5-hydroxytryptamine receptor 2A) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
L61F (p.Leu61Phe) variant details
- p.Leu61Phe
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.226
- REVEL 0.03
- MetaLR 0.05
- MetaSVM -1.06
- CADD 22.40
- PolyPhen-2 0.04
- SIFT 0.52
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available