K146T (p.Lys146Thr) variant of HTR2A (5-hydroxytryptamine receptor 2A)
K146T (p.Lys146Thr) in HTR2A (5-hydroxytryptamine receptor 2A) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data, published literature, and structural context.
K146T (p.Lys146Thr) variant details
- p.Lys146Thr
- gnomAD 13-46892566-T-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.336
- REVEL 0.19
- MetaLR 0.14
- MetaSVM -0.90
- CADD 19.90
- PolyPhen-2 0.04
- SIFT 0.58
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available
- Literature evidence available