L6P (p.Leu6Pro) variant of HRAS (GTPase HRas)
L6P (p.Leu6Pro) in HRAS (GTPase HRas) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.70 / 1. The record also includes population frequency data and structural context.
L6P (p.Leu6Pro) variant details
- p.Leu6Pro
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.699
- REVEL 0.84
- AlphaMissense 1.00
- MetaLR 0.62
- MetaSVM 0.42
- CADD 28.30
- PolyPhen-2 1.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available