H27Y (p.His27Tyr) variant of HRAS (GTPase HRas)
H27Y (p.His27Tyr) in HRAS (GTPase HRas) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data and structural context.
H27Y (p.His27Tyr) variant details
- p.His27Tyr
- Ensembl rs2133994418
- Missense
- Variant Prioritization Score for Impact Estimate 0.446
- REVEL 0.45
- AlphaMissense 0.46
- MetaLR 0.22
- MetaSVM -0.58
- CADD 22.90
- PolyPhen-2 0.93
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available