P87R (p.Pro87Arg) variant of HLA-DQB1 (P01920)
P87R (p.Pro87Arg) in HLA-DQB1 (P01920) is a missense change. Clinical records from EBI and UniProt describe it as benign in the context of in allele DQB1*03:23, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, a. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes published literature and structural context.
P87R (p.Pro87Arg) variant details
- p.Pro87Arg
- rs1130380
- UniProt VAR 062711
- Benign
- in allele DQB1*03:23, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, a
- Missense
- Variant Prioritization Score for Impact Estimate 0.217
- AlphaMissense 0.35
- MetaLR 0.00
- MetaSVM -0.91
- PolyPhen-2 0.00
- SIFT 0.17
- EBI: Benign (in allele DQB1*03:23, allele DQB1*03:25, allele DQB1*04:01, alle)
- UniProt: Benign (in allele DQB1*03:23, allele DQB1*03:25, allele DQB1*04:01, alle)
- Structural context available
- Literature evidence available