Y31H (p.Tyr31His) variant of HLA-C (P10321)
Y31H (p.Tyr31His) in HLA-C (P10321) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data and structural context.
Y31H (p.Tyr31His) variant details
- p.Tyr31His
- rs281860324
- ExAC rs281860324
- gnomAD rs281860324
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.278
- REVEL 0.13
- CADD 25.10
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.1e-06)
- Structural context available