M4V (p.Met4Val) variant of HLA-C (P10321)
M4V (p.Met4Val) in HLA-C (P10321) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
M4V (p.Met4Val) variant details
- p.Met4Val
- NCI-TCGA Cosmic COSV1008
- cosmic curated COSV10088
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.241
- REVEL 0.17
- CADD 3.87
- PolyPhen-2 0.03
- SIFT 0.12
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available