F46L (p.Phe46Leu) variant of HLA-C (P10321)
F46L (p.Phe46Leu) in HLA-C (P10321) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
F46L (p.Phe46Leu) variant details
- p.Phe46Leu
- ExAC rs281860341
- gnomAD rs281860341
- Missense
- Variant Prioritization Score for Impact Estimate 0.324
- REVEL 0.18
- CADD 23.30
- PolyPhen-2 1.00
- SIFT 0.02
- Most common in the Non-Finnish European population (allele frequency 1e-06)
- Structural context available