E21D (p.Glu21Asp) variant of HLA-C (P10321)
E21D (p.Glu21Asp) in HLA-C (P10321) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
E21D (p.Glu21Asp) variant details
- p.Glu21Asp
- ExAC rs769594453
- gnomAD rs769594453
- Missense
- Variant Prioritization Score for Impact Estimate 0.296
- REVEL 0.14
- CADD 19.20
- PolyPhen-2 0.14
- SIFT 0.04
- Most common in the Latino/Admixed American population (allele frequency 3.7e-05)
- Structural context available