Y51C (p.Tyr51Cys) variant of HLA-B (P01889)
Y51C (p.Tyr51Cys) in HLA-B (P01889) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data and structural context.
Y51C (p.Tyr51Cys) variant details
- p.Tyr51Cys
- rs281864590
- NCI-TCGA Cosmic COSV1013
- cosmic curated COSV10131
- ExAC rs281864590
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.395
- REVEL 0.33
- CADD 25.50
- PolyPhen-2 1.00
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available