R45S (p.Arg45Ser) variant of HLA-B (P01889)
R45S (p.Arg45Ser) in HLA-B (P01889) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data and structural context.
R45S (p.Arg45Ser) variant details
- p.Arg45Ser
- gnomAD rs45509993
- Missense
- Variant Prioritization Score for Impact Estimate 0.283
- REVEL 0.13
- CADD 18.50
- PolyPhen-2 1.00
- SIFT 0.01
- Most common in the South Asian population (allele frequency 3.5e-05)
- Structural context available