L12P (p.Leu12Pro) variant of HLA-B (P01889)
L12P (p.Leu12Pro) in HLA-B (P01889) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
L12P (p.Leu12Pro) variant details
- p.Leu12Pro
- gnomAD rs1386205687
- Missense
- Variant Prioritization Score for Impact Estimate 0.342
- REVEL 0.20
- CADD 28.40
- PolyPhen-2 1.00
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 1.5e-06)
- Structural context available