H27P (p.His27Pro) variant of HLA-B (P01889)
H27P (p.His27Pro) in HLA-B (P01889) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
H27P (p.His27Pro) variant details
- p.His27Pro
- cosmic curated COSV69522
- gnomAD rs1421938775
- Missense
- Variant Prioritization Score for Impact Estimate 0.364
- REVEL 0.26
- CADD 27.40
- PolyPhen-2 0.92
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 7e-05)
- Structural context available