H27L (p.His27Leu) variant of HLA-B (P01889)
H27L (p.His27Leu) in HLA-B (P01889) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
H27L (p.His27Leu) variant details
- p.His27Leu
- gnomAD rs1421938775
- Missense
- Variant Prioritization Score for Impact Estimate 0.362
- REVEL 0.27
- CADD 26.90
- PolyPhen-2 0.54
- SIFT 0.01
- Most common in the South Asian population (allele frequency 2e-05)
- Structural context available