E21K (p.Glu21Lys) variant of HLA-B (P01889)
E21K (p.Glu21Lys) in HLA-B (P01889) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
E21K (p.Glu21Lys) variant details
- p.Glu21Lys
- gnomAD rs1231905919
- Missense
- Variant Prioritization Score for Impact Estimate 0.216
- REVEL 0.25
- CADD 13.70
- PolyPhen-2 0.99
- SIFT 0.07
- Most common in the South Asian population (allele frequency 5.3e-05)
- Structural context available