E21* (p.Glu21Ter) variant of HLA-B (P01889)
E21* (p.Glu21Ter) in HLA-B (P01889) is a protein-truncating change. Clinical records from UniProt describe it as variant assessed as somatic; high impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
E21* (p.Glu21Ter) variant details
- p.Glu21Ter
- rs1231905919
- NCI-TCGA Cosmic COSV1013
- cosmic curated COSV10131
- gnomAD rs1231905919
- Variant assessed as somatic; high impact.
- Stop Gained
- Variant Prioritization Score for Impact Estimate 0.321
- CADD 34.00
- UniProt: Variant assessed as somatic; high impact.
- Most common in the Non-Finnish European population (allele frequency 1.5e-06)
- Structural context available