L12P (p.Leu12Pro) variant of HLA-A (P04439)
L12P (p.Leu12Pro) in HLA-A (P04439) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
L12P (p.Leu12Pro) variant details
- p.Leu12Pro
- cosmic curated COSV65143
- Missense
- Variant Prioritization Score for Impact Estimate 0.336
- REVEL 0.20
- CADD 24.10
- PolyPhen-2 1.00
- SIFT 0.01
- Most common in the Ashkenazi Jewish population (allele frequency 5.8e-05)
- Structural context available