E457K (p.Glu457Lys) variant of HIF1A (Hypoxia-inducible factor 1-alpha)

E457K (p.Glu457Lys) in HIF1A (Hypoxia-inducible factor 1-alpha) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as likely pathogenic in the context of Maffucci syndrome.

E457K (p.Glu457Lys) variant details