S9Y (p.Ser9Tyr) variant of HCN1 (O60741)
S9Y (p.Ser9Tyr) in HCN1 (O60741) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data and structural context.
S9Y (p.Ser9Tyr) variant details
- p.Ser9Tyr
- TOPMed rs1282790075
- Missense
- Variant Prioritization Score for Impact Estimate 0.509
- REVEL 0.42
- AlphaMissense 0.08
- MetaLR 0.68
- MetaSVM -0.21
- CADD 24.50
- PolyPhen-2 0.09
- Most common in the African/African-American population (allele frequency 4.1e-05)
- Structural context available