P77T (p.Pro77Thr) variant of HCN1 (O60741)
P77T (p.Pro77Thr) in HCN1 (O60741) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
P77T (p.Pro77Thr) variant details
- p.Pro77Thr
- Ensembl rs1561248449
- Missense
- Variant Prioritization Score for Impact Estimate 0.228
- REVEL 0.18
- AlphaMissense 0.96
- MetaLR 0.57
- MetaSVM 0.05
- CADD 0.24
- PolyPhen-2 0.62
- Most common in the African/African-American population (allele frequency 3.2e-05)
- Structural context available