P77Q (p.Pro77Gln) variant of HCN1 (O60741)
P77Q (p.Pro77Gln) in HCN1 (O60741) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data and structural context.
P77Q (p.Pro77Gln) variant details
- p.Pro77Gln
- TOPMed rs1348079874
- gnomAD rs1348079874
- Missense
- Variant Prioritization Score for Impact Estimate 0.426
- REVEL 0.27
- CADD 17.60
- PolyPhen-2 0.04
- SIFT 0.42
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available