G74R (p.Gly74Arg) variant of HCN1 (O60741)
G74R (p.Gly74Arg) in HCN1 (O60741) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data and structural context.
G74R (p.Gly74Arg) variant details
- p.Gly74Arg
- ExAC rs747284102
- gnomAD rs747284102
- Missense
- Variant Prioritization Score for Impact Estimate 0.404
- REVEL 0.39
- CADD 15.90
- PolyPhen-2 0.00
- SIFT 0.66
- Most common in the East Asian population (allele frequency 2.8e-05)
- Structural context available