G64S (p.Gly64Ser) variant of HCN1 (O60741)
G64S (p.Gly64Ser) in HCN1 (O60741) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
G64S (p.Gly64Ser) variant details
- p.Gly64Ser
- gnomAD rs1365874820
- Missense
- Variant Prioritization Score for Impact Estimate 0.351
- REVEL 0.26
- CADD 20.00
- PolyPhen-2 0.86
- SIFT 0.37
- Most common in the Latino/Admixed American population (allele frequency 3.3e-05)
- Structural context available