F21Y (p.Phe21Tyr) variant of HCN1 (O60741)
F21Y (p.Phe21Tyr) in HCN1 (O60741) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
F21Y (p.Phe21Tyr) variant details
- p.Phe21Tyr
- gnomAD rs1470715710
- Missense
- Variant Prioritization Score for Impact Estimate 0.238
- REVEL 0.14
- CADD 18.20
- PolyPhen-2 0.02
- SIFT 0.27
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available