F21L (p.Phe21Leu) variant of HCN1 (O60741)
F21L (p.Phe21Leu) in HCN1 (O60741) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
F21L (p.Phe21Leu) variant details
- p.Phe21Leu
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.323
- REVEL 0.14
- AlphaMissense 0.72
- MetaLR 0.78
- MetaSVM 0.32
- CADD 18.80
- PolyPhen-2 0.05
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available