R55T (p.Arg55Thr) variant of GRN (Progranulin)
R55T (p.Arg55Thr) in GRN (Progranulin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data and structural context.
R55T (p.Arg55Thr) variant details
- p.Arg55Thr
- TOPMed rs2048350633
- Missense
- Variant Prioritization Score for Impact Estimate 0.187
- REVEL 0.16
- CADD 10.50
- PolyPhen-2 0.09
- SIFT 0.36
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available