P60R (p.Pro60Arg) variant of GRN (Progranulin)
P60R (p.Pro60Arg) in GRN (Progranulin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
P60R (p.Pro60Arg) variant details
- p.Pro60Arg
- ExAC rs777882796
- gnomAD rs777882796
- Missense
- Variant Prioritization Score for Impact Estimate 0.324
- REVEL 0.28
- CADD 14.00
- PolyPhen-2 0.57
- SIFT 0.35
- Most common in the Non-Finnish European population (allele frequency 3.6e-06)
- Structural context available