G59S (p.Gly59Ser) variant of GRN (Progranulin)
G59S (p.Gly59Ser) in GRN (Progranulin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.06 / 1. The record also includes population frequency data, published literature, and structural context.
G59S (p.Gly59Ser) variant details
- p.Gly59Ser
- gnomAD 17-44349462-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.0581
- REVEL 0.04
- CADD 0.87
- PolyPhen-2 0.00
- SIFT 0.74
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available