G59D (p.Gly59Asp) variant of GRN (Progranulin)
G59D (p.Gly59Asp) in GRN (Progranulin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.10 / 1. The record also includes population frequency data and structural context.
G59D (p.Gly59Asp) variant details
- p.Gly59Asp
- cosmic curated COSV99029
- gnomAD rs1456999060
- Missense
- Variant Prioritization Score for Impact Estimate 0.099
- REVEL 0.12
- CADD 0.06
- PolyPhen-2 0.08
- SIFT 0.62
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available