G58S (p.Gly58Ser) variant of GRN (Progranulin)
G58S (p.Gly58Ser) in GRN (Progranulin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
G58S (p.Gly58Ser) variant details
- p.Gly58Ser
- ExAC rs758199939
- TOPMed rs758199939
- gnomAD rs758199939
- Missense
- Variant Prioritization Score for Impact Estimate 0.228
- REVEL 0.14
- CADD 16.80
- PolyPhen-2 0.14
- SIFT 0.16
- Most common in the Non-Finnish European population (allele frequency 2.9e-05)
- Structural context available