F25L (p.Phe25Leu) variant of GRN (Progranulin)
F25L (p.Phe25Leu) in GRN (Progranulin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.06 / 1. The record also includes population frequency data, published literature, and structural context.
F25L (p.Phe25Leu) variant details
- p.Phe25Leu
- gnomAD 17-44349237-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.0617
- REVEL 0.04
- CADD 1.90
- PolyPhen-2 0.00
- SIFT 0.99
- Population evidence available
- Structural context available
- Literature evidence available