C41Y (p.Cys41Tyr) variant of GRN (Progranulin)
C41Y (p.Cys41Tyr) in GRN (Progranulin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.67 / 1. The record also includes population frequency data and structural context.
C41Y (p.Cys41Tyr) variant details
- p.Cys41Tyr
- ExAC rs760088921
- gnomAD rs760088921
- Missense
- Variant Prioritization Score for Impact Estimate 0.668
- REVEL 0.58
- CADD 27.00
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available