C26Y (p.Cys26Tyr) variant of GRN (Progranulin)
C26Y (p.Cys26Tyr) in GRN (Progranulin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.72 / 1. The record also includes population frequency data and structural context.
C26Y (p.Cys26Tyr) variant details
- p.Cys26Tyr
- ExAC rs780086363
- TOPMed rs780086363
- gnomAD rs780086363
- Missense
- Variant Prioritization Score for Impact Estimate 0.723
- REVEL 0.69
- CADD 25.10
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available