A37T (p.Ala37Thr) variant of GRN (Progranulin)
A37T (p.Ala37Thr) in GRN (Progranulin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data and structural context.
A37T (p.Ala37Thr) variant details
- p.Ala37Thr
- gnomAD rs2048348973
- Missense
- Variant Prioritization Score for Impact Estimate 0.161
- REVEL 0.08
- CADD 15.70
- PolyPhen-2 0.03
- SIFT 0.50
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available