W100C (p.Trp100Cys) variant of GRM5 (P41594)
W100C (p.Trp100Cys) in GRM5 (P41594) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.64 / 1. The record also includes population frequency data.
W100C (p.Trp100Cys) variant details
- p.Trp100Cys
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.637
- REVEL 0.60
- MetaLR 0.44
- MetaSVM -0.21
- CADD 27.00
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)