V2A (p.Val2Ala) variant of GRM5 (P41594)
V2A (p.Val2Ala) in GRM5 (P41594) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data.
V2A (p.Val2Ala) variant details
- p.Val2Ala
- ExAC rs78375107
- TOPMed rs78375107
- gnomAD rs78375107
- Missense
- Variant Prioritization Score for Impact Estimate 0.434
- REVEL 0.34
- MetaLR 0.69
- MetaSVM 0.30
- CADD 21.60
- PolyPhen-2 0.03
- SIFT 0.08
- Most common in the Latino/Admixed American population (allele frequency 0.00085)