S98Y (p.Ser98Tyr) variant of GRM5 (P41594)
S98Y (p.Ser98Tyr) in GRM5 (P41594) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.67 / 1. The record also includes population frequency data.
S98Y (p.Ser98Tyr) variant details
- p.Ser98Tyr
- rs781196829
- NCI-TCGA Cosmic COSV5959
- cosmic curated COSV59595
- 1000Genomes rs781196829
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.674
- REVEL 0.75
- MetaLR 0.50
- MetaSVM -0.07
- CADD 25.50
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the 1KG:ESN population (allele frequency 0.0049)