N88S (p.Asn88Ser) variant of GRM5 (P41594)
N88S (p.Asn88Ser) in GRM5 (P41594) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.65 / 1. The record also includes population frequency data.
N88S (p.Asn88Ser) variant details
- p.Asn88Ser
- NCI-TCGA Cosmic COSV5959
- cosmic curated COSV59590
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.652
- REVEL 0.63
- MetaLR 0.78
- MetaSVM 0.68
- CADD 24.50
- PolyPhen-2 0.55
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)