L4M (p.Leu4Met) variant of GRM5 (P41594)
L4M (p.Leu4Met) in GRM5 (P41594) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data.
L4M (p.Leu4Met) variant details
- p.Leu4Met
- cosmic curated COSV59595
- gnomAD rs1447134591
- Missense
- Variant Prioritization Score for Impact Estimate 0.451
- REVEL 0.40
- MetaLR 0.80
- MetaSVM 0.26
- CADD 22.30
- PolyPhen-2 0.36
- SIFT 0.06
- Most common in the Non-Finnish European population (allele frequency 9e-07)