G125S (p.Gly125Ser) variant of GRM5 (P41594)
G125S (p.Gly125Ser) in GRM5 (P41594) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data.
G125S (p.Gly125Ser) variant details
- p.Gly125Ser
- cosmic curated COSV10518
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.528
- REVEL 0.37
- MetaLR 0.68
- MetaSVM 0.29
- CADD 20.70
- PolyPhen-2 0.04
- SIFT 0.64
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Middle Eastern population (allele frequency 0.00017)