G125D (p.Gly125Asp) variant of GRM5 (P41594)
G125D (p.Gly125Asp) in GRM5 (P41594) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.68 / 1. The record also includes population frequency data.
G125D (p.Gly125Asp) variant details
- p.Gly125Asp
- ExAC rs776573553
- TOPMed rs776573553
- gnomAD rs776573553
- Missense
- Variant Prioritization Score for Impact Estimate 0.682
- REVEL 0.58
- MetaLR 0.84
- MetaSVM 0.74
- CADD 23.20
- PolyPhen-2 0.60
- SIFT 0.06
- Most common in the African/African-American population (allele frequency 3e-05)