E121D (p.Glu121Asp) variant of GRM5 (P41594)
E121D (p.Glu121Asp) in GRM5 (P41594) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.49 / 1. The record also includes population frequency data.
E121D (p.Glu121Asp) variant details
- p.Glu121Asp
- ExAC rs775240392
- gnomAD rs775240392
- Missense
- Variant Prioritization Score for Impact Estimate 0.494
- REVEL 0.57
- MetaLR 0.59
- MetaSVM 0.01
- CADD 18.30
- PolyPhen-2 0.92
- SIFT 0.97
- Most common in the Non-Finnish European population (allele frequency 9e-07)