I61T (p.Ile61Thr) variant of GRIA1 (Glutamate receptor 1)
I61T (p.Ile61Thr) in GRIA1 (Glutamate receptor 1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data and structural context.
I61T (p.Ile61Thr) variant details
- p.Ile61Thr
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.509
- REVEL 0.46
- MetaLR 0.50
- MetaSVM 0.11
- CADD 22.30
- PolyPhen-2 0.08
- SIFT 0.55
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the HGDP:MBUTI population (allele frequency 0.29)
- Structural context available