C3Y (p.Cys3Tyr) variant of GNAS (P63092)

Name: GNAS C3Y (p.Cys3Tyr) variant | CATVariant
Creator: Center for Precision Medicine and Data Sciences
Published: 2026-08-20
License: https://catvariant.com/terms-of-use

C3Y (p.Cys3Tyr) in GNAS (P63092) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.64 / 1. The record also includes population frequency data and structural context.

C3Y (p.Cys3Tyr) variant details

p.Cys3Tyr
NCI-TCGA Cosmic COSV9966
cosmic curated COSV99668
Variant assessed as somatic; moderate impact.
Missense
Variant Prioritization Score for Impact Estimate 0.644
REVEL 0.76
CADD 19.50
PolyPhen-2 1.00
SIFT 0.00
UniProt: Variant assessed as somatic; moderate impact.
Population evidence available
Structural context available