G92E (p.Gly92Glu) variant of GCK (Hexokinase-4)
G92E (p.Gly92Glu) in GCK (Hexokinase-4) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.62 / 1. The record also includes population frequency data and structural context.
G92E (p.Gly92Glu) variant details
- p.Gly92Glu
- NCI-TCGA Cosmic COSV6175
- cosmic curated COSV61753
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.618
- REVEL 0.64
- AlphaMissense 0.68
- MetaLR 0.14
- MetaSVM -0.83
- CADD 21.30
- PolyPhen-2 1.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available