Y81C (p.Tyr81Cys) variant of FUS (RNA-binding protein FUS)
Y81C (p.Tyr81Cys) in FUS (RNA-binding protein FUS) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.56 / 1. The record also includes population frequency data and structural context.
Y81C (p.Tyr81Cys) variant details
- p.Tyr81Cys
- cosmic curated COSV54215
- TOPMed rs2079219375
- Missense
- Variant Prioritization Score for Impact Estimate 0.558
- REVEL 0.50
- CADD 26.60
- PolyPhen-2 0.85
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 5.8e-05)
- Structural context available