P21S (p.Pro21Ser) variant of FUS (RNA-binding protein FUS)
P21S (p.Pro21Ser) in FUS (RNA-binding protein FUS) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data, published literature, and structural context.
P21S (p.Pro21Ser) variant details
- p.Pro21Ser
- gnomAD 16-31182535-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.451
- REVEL 0.32
- CADD 22.50
- PolyPhen-2 0.09
- SIFT 0.12
- Most common in the East Asian population (allele frequency 2.8e-05)
- Structural context available
- Literature evidence available