G34R (p.Gly34Arg) variant of FUS (RNA-binding protein FUS)
G34R (p.Gly34Arg) in FUS (RNA-binding protein FUS) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.62 / 1. The record also includes population frequency data, published literature, and structural context.
G34R (p.Gly34Arg) variant details
- p.Gly34Arg
- gnomAD 16-31182574-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.62
- REVEL 0.45
- MetaLR 0.71
- MetaSVM 0.68
- CADD 28.30
- PolyPhen-2 0.56
- SIFT 0.04
- Most common in the Non-Finnish European population (allele frequency 9.3e-07)
- Structural context available
- Literature evidence available