L28I (p.Leu28Ile) variant of FTO (Q9C0B1)
L28I (p.Leu28Ile) in FTO (Q9C0B1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data, published literature, and structural context.
L28I (p.Leu28Ile) variant details
- p.Leu28Ile
- gnomAD 16-53810176-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.417
- REVEL 0.21
- MetaLR 0.28
- MetaSVM -0.41
- CADD 22.90
- PolyPhen-2 0.99
- SIFT 0.67
- Population evidence available
- Structural context available
- Literature evidence available